New Trends in Solid-Phase Pool Libraries

1 Bead-Based Libraries High-Throughput Synthesis 

SYNTHETIC ORGANIC LIBRARIES SOLID-PHASE POOL LIBRARIES 

The two epoxide enantiomers (i-) and (-) 7.71 were selected as chemical starting points for library generation Their synthesis from shikimic acid with reasonable overall yields was already known (248, 249), and they had a carboxylic acid handle for SPS. The other key intermediates were the three benzylnitrone carboxylic acids 7.72a-c, which were prepared from the corresponding benzyl alcohols (250,251) (Fig. 7.40). The two epoxycyclohexenols were supported onto a PEG-based resin, loaded with a photolabile linker, to give resin-bound 7.73a,b (from now on only one enantiomer will be shown in the figures, but the synthetic pathway was continued with both 

54 monomers 90% conversion and purity 8 monomers 70% conversion and purity 

Monomer rehearsal was followed by a model library synthesis aimed at confirming the feasibility of mix-and-split synthesis for the selected SP hbrary synthetic scheme and to check for unwanted interactions of rehearsed building blocks at different reaction sites than the ones expected. A series of eight monomer representatives from 

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