Nevirapine animal model

Shenton, J.M. et al., Characterization of a potential animal model of an idiosyncratic drug reaction Nevirapine-induced skin rash in the rat. Chem. Res. Toxicol., 16, 1078, 2003... 

The main obstacle to studying the mechanism of delayed skin ADRs is a lack of animal models. With the exception of nevirapine (Shenton et al. 2005), the vast... 

Animal Model of Nevirapine-Induced Skin Rash.441... 

In 2003, Shenton et al. reported a novel animal model of a drug-induced idiosyncratic reaction nevirapine-induced skin rash in the female Brown Norway rat. This animal model does not reproduce severe skin rashes such as TEN and SJS, nor does it reproduce the liver toxicity observed in some nevirapine-treated patients. However, the skin rash that develops in nevirapine-treated rats closely resembles the mild erythematous rash observed in patients (Shenton et al. 2003). 

In the animal model, based on variations between strains and males versus females, there was a correlation between the blood level of nevirapine and the incidence of rash (Chen et al. 2008). In addition, inhibition of metabolism by aminobenzotriazole led to higher nevirapine blood levels and rash at a lower dose, with lower levels of most metabolites. However, there was one metabolite... 

Sanne I, Mommeja-Marin H, Hinkle J, Bartlett JA, Lederman MM, Maartens G, Wakeford C, Shaw A, Quinn J, Gish RG, Rousseau F (2005) Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects. J Infect Dis 191 825-829 Shenton JM, Teranishi M, Abu-Asab MS, Yager JA, Uetrecht JP (2003) Characterization of a potential animal model of an idiosyncratic drug reaction nevirapine-induced skin rash in the rat. Chem Res Toxicol 16(9) 1078-1089... 

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