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Neutrophils biochemical defects

Extensive studies into the association of this cytochrome b with CGD neutrophils were performed by Segal and Jones, and by other workers, in the late 1970s and early 1980s. The cytochrome was completely absent (as determined by the absence of a distinctive absorption spectrum in spectroscopic studies) in almost all cases of X-linked CGD, but present at decreased levels in female relatives of these patients. In almost all cases of autosomal recessive CGD, the cytochrome was present but non-functional, in that it did not become reduced upon cellular activation. This indicated both the heterogeneous nature of the disease and also that some other biochemical defect was responsible for impaired function in these patients. Hence, the search was on for other components of the NADPH oxidase. [Pg.267]

Thus a variety of biochemical defects can compromise the phagocytic function of neutrophils (see Table 8). [Pg.254]

In this overview we have highlighted the normal biochemical functions of platelets, neutrophils, and lymphocytes. We have attempted to relate defects in these cells to derangement in function. With the explosion of knowledge in the chemistry, immunology, and molecular biology of these cells, it is to be hoped that in the near future we will come to a fuller understanding of the basis of hematological disease. [Pg.260]

The leukocyte response is inadequate in a great number of clinical conditions. Most of the disorders described have been associated with an increased susceptibility to infections. However, the biochemical or molecular level of the various defects have not been clearly established, except for some genetically determined deficiencies. A few examples of neutrophil abnormalities will be given in the two subsequent sections, but for a more complete insight into PMN phagocytic disorders, general reviews and monographs are available (K2, B2, Wl, W3, K3). [Pg.156]


See other pages where Neutrophils biochemical defects is mentioned: [Pg.265]    [Pg.301]    [Pg.235]    [Pg.250]    [Pg.10]    [Pg.57]    [Pg.159]   
See also in sourсe #XX -- [ Pg.250 , Pg.251 , Pg.252 , Pg.253 ]




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Neutrophils

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