Neutrophilic reversible allograft dysfunction

Figure 2 (A). Typical FEVi evolution in a patient with late acute BOS. After a very stable period of several years, there is a documented acute rejection episode (arrow), with some improvement of the FEVi after classical treatment, however, quickly followed by a very rapid decline in the FEVi, indicative of fBOS. (B). Natural evolution of FEVi in a patient with slowly progressing BOS and biopsy-proven OB. During the last months of evolution, there appears to be a spontaneous arrest in the FEVi decline. This is compatible with the NRAD phenotype, left untreated and leading to pure OB at the end. (C). Another patient with BOS, who has a spontaneous arrest of the FEVi decline, with a plateau, reached after several months of evolution. Abbreviations. FEVi, forced expiratory volume in one second BOS, bronchiolitis obliterans syndrome fBOS, fibrotic BOS OB, obliterative bronchiolitis NRAD, neutrophilic reversible allograft dysfunction.

Abbreviations. NRAD, neutrophilic reversible allograft dysfunction fBOS, fibrotic bronchiolitis obliterans syndrome BAL, bronchoalveolar lavage FEVi, forced expiratory volume in one second. Source. From Ref. 13. 

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