Neurovascular coupling

Cauli, B., Tong, X. K., Rancillac, A. el al (2004). Cortical GABA interneurons in neurovascular coupling relays for subcortical vasoactive pathways. J. Neurosci. 

Hay don PG, Carmignoto G (2006) Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86 1009-1031. 

Step 3 Propose testable hypotheses to test the causal/mechanistic model developed in Step 2 POL make predictions based on experimental observables). Because of the energy constraint in Step 2, experiments that reflect energy utilization (glucose, oxygen, or blood flow in cases of neurovascular coupling) can provide important insight for evaluating theoretical predictions. 

Fig. 1 Schematic diagram of neurovascular coupling assessment system...

In this study, we applied non-invasive approach for evaluating focal cerebral ischemia. The pattern of SSEP response shows that the Pl-Nl amplitude was sipiflcant attenuated but the PI latency was not significant decayed. The hemodynamic response was detected when somatosensory evoke potential was measured from surface recording region. The result of time frequency analysis shows that the high frequency shifts in the initial of the SSEPs. Several studies have also indicated that phenomenon may be caused by brain injury. The results of neurovascular coupling are consistent with previous studies [9]. 

Prevot V, Rialas CM, Croix D, Salzet M, Dupouy JP, Poulain P, Beauvillain JC, Stefano GB (1998) Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence neurovascular regulation. Brain Res 790 236-244... 

Leybaert L. Neurobarrier coupling in the brain A partner of neurovascular and neurometaboUc coupling Journal of Cerebral Blood Flow Metabolism. 2005 25 2-16. 

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