Neurotoxins, organophosphorus

Rainina, E. Simonian, A. fremenco, A. Varfolomeyev, S. Wild, J., The development of a new biosensor based on recombinant E. coli for the direct detection of organophosphorus neurotoxins, Biosens. Bioelectron. 1996, 11, 991 1000... 

Russell, R.J., Pishko, M.V., Simonian, A.J., Wild, J.R. (1999). Poly(ethylene glycol) hydrogel-encapsulated fluorophore-enzyme conjugates for direct detection of organophosphorus neurotoxins. Anal. Chem. 71 4909-12. 

An example of absolutely cumulative toxicity is afforded by tri-o-cresyl phosphate or TOCP (figure 2,9). This compound is a cholinesterase inhibitor and neurotoxin. In chickens, an acute dose of 30 mg/kg has a severe toxic effect, which is produced to the same extent by a dose of 1 (mg/kg)/day given for 30 days. This effect may of course be produced by accumulation of the compound in vivo to a threshold toxic level, or it may result from the accumulation of the effect, as it probably does in the case of TOCP. Thus, the inhibition of cholinesterase enzymes by organophosphorus compounds may... 

Wang J., Krause R., Block K., Musameh M., Mulchandani A., Mulchandani P., Chen W., and Schoning M. J., Dual amperometric-potentiometric biosensor detection system for monitoring organophosphorus neurotoxins. Anal. Chim. Acta, 469, 197-203,... 

There is a class of synthetic phosphorus compounds that are often mentioned in a biological context. These are the organophosphorus poisons (neurotoxins and pesticides). They all have the general structure 1... 

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