Neurotoxicity neurofibrillary tangles

Ingestion > inhalation. Osteomalacia (softening of bones). Neurotoxicity effects include neurofibrillary tangles behavioral changes possible causative agent of Alzheimer s disease, some human dementia syndromes. Exposure to Al dusts can trigger lung fibrosis. 

In 1937, a study found that aluminum salts caused uniformly fatal, neurotoxic symptoms when injected intracerebrally in animals (Scherp and Church 1937). Experimental work in the 1960s later showed that intracerebral or intrathecal injections of aluminum in rabbits caused neurotoxic reactions and neurofibrillary tangles (NFTs) similar to those observed in Alzheimer s disease (AD) (Klatzo et al. 1965 Terry and Pena 1965). Between 1973 and 1976, three landmark articles reported aluminum in the NFTs of AD patients (Crapper 1974 Crapper et al. 1973, 1976). 

Environmental and nutritional factors may also affect the development of Alzheimer disease and other mental illness. Aluminum frequently accumulates in the neurons containing neurofibrillary tangles. Copper and zinc ions can cause the amyloid Ap to aggregate. However, Zn + may actually protect against neurotoxicity. The amino acid P-N-methylamino-L-alanine, a constituent of the toxic seeds of a type of palm Cycas circimlis L.), may have induced both AES and Guam disease, a condition resembling Parkinson disease, in a population in Guam that traditionally used these seeds as food. ... 

Pre- and post-excitatory amino acid markers in Alzheimer s disease -Amyloid neurotoxicity Neurotrophic factors Neurofibrillary tangles... 

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