Neurotoxicity ethambutol

Ethambutol (Myambutel) [Antitubercular Agent] Uses Pulm TB other mycobacterial Infxns, MAC Action i RNA synth Dose Adults Feds >12 y. 15-25 mg/kg/d PO single dose X in renal impair, take w/ food, avoid antacids Caution [B, +] Contra Unconscious pts, optic neuritis Disp Tabs SE HA, hyperuricemia, acute gout, abd pain, T LFTs, optic neuritis, GI upset Interactions T Neurotox W/ neurotoxic drugs X effects W/ A1 salts EMS May affect glucose (hypoglycemia) may cause vision problems OD Sxs unknown activated charcoal may be effective symptomatic and supportive... 

Synthetic chemicals with neurotoxic potential (Table 2) are most commonly encountered in the form of prescription (ethambutol, isoniazid, vincristine)... 

Nervous system The adverse effects of antituberculosis drugs on the nervous system have been reviewed [1 ]. Isoniazid is most often associated with nervous system reactions, most prominently peripheral neuropathy, psychosis, and seizures. Optic neuropathy can occur with ethambutol and ototoxicity and neuromuscular blockade with aminoglycosides. Cycloserine can cause psychosis and seizures, and the psychosis in particular limits its use. Fluoroquinolones are rare causes of seizures and delirium. Significant neurotoxicity has not been documented with newer forms of therapy under development. 

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