Neuropeptide research

Silberring, J., Ekman, R., Desiderio, D.M., and Nibbering, N. M., Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research, Wiley Interscience, New York, 2002. 

Figure 2.6. Schematic of an electrospray ionization (ESI) source. Reprinted from A. Westman-Brinkmalm and G. Brinkmalm (2002). In Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research, J. Silberring and R. Ekman (eds.) New York John Wiley Sons, 47-105. With permission of John Wiley Sons, Inc.

Figure 2.9. Schematic of a matrix-assisted laser desorption/ionization (MALDI) event. The SEM micrograph depicts sinapinic acid-equine myoglobin crystal from a sample prepared according to the dried drop sample preparation method. In the desorption event neutral matrix molecules (M), positive matrix ions (M+), negative matrix ions (M-), neutral analyte molecules (N), positive analyte ions (+), and negative analyte ions (-) are created and/or transferred to the gas phase. Reprinted from A. Westman-Brinkmalm and G. Brinkmalm (2002). In Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research, J. Silberring and R. Ekman (eds.) New York John Wiley Sons, 47-105. With permission of John Wiley Sons, Inc.

Jerzy Silberring and Rolf Eckman Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research... 

Quirion R, Dam TV, Sarrieau A, Rostene W. 1989. Receptor autoradiography in neuropeptide research. Brain imaging techniques and application. Sharif NA, Lewis ME, editors. Chichester, England Ellis Horwood pp. 77-94. 

Van Leeuwen, F.W. (2004) Neuropeptide research discloses part of the secrets of Alzheimer s disease neuropathogenesis state of the art 2004. Neurosci. Lett., 361, 124-127. 

Nemeroff CB New vistas in neuropeptide research in neuropsychiatry focus on corticotropin-releasing factor. Neuropsychopharmacology 6 69-75, 1992... 

Neuropeptide research will in all probability allow the development of new active substances that are more effective, more specific, and safer than the psychopharmaceuticals in current use. 

RfteeN years have elapsed since Alvin N. Starratt and Brian E. Brown released their pioneering publication announcing the initial determination of a primary structure for an insect neuropeptide—the penta-peptide proctolin. In the early 1980s, only a few American, Japanese, and European universities, as well as the Zoecon Corporation in the United States, were engaged in insect neuropeptide research. Neuropeptide discoveries in vertebrates and molluscs—and the advent of exquisitely sensitive techniques for isolation, sequence determination, and synthesis of neuropeptides—rapidly accelerated discoveries in both the mammalian and insect arenas. More than SO insect neuropeptides have been sequenced and reported in the literature, and that number is increasing rapidly. Concomitant with these developments have been several symposia, conferences, and workshops that address various aspects of insect neuroscience. 

This work describes in some detail those parameters that were identified, at the start of the coordinated research project, as being important in this assessment process. Since a decision was taken at the start of the project to concentrate research on the model peptide DOTA-Tyr -octreotate (DOTATATE), examples from the field of radiolabelled neuropeptide research are included. Details concerning the following topics are discussed in this paper ... 

Jerzy Silberring and Rolf Eckman Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research J. Wayne Rabalais Principles and Applications of Ion Scattering Spectrometry Surface Chemical and Structural Analysis Mahmoud Hamdan and Pier Giorgio Righetti Proteomics Today Protein Assessment and Biomarkers Using Mass Spectrometry, 2D Electrophoresis, and Microarray Technology... 

Nyberg F. Neuropeptides in CNS tissue and body fluids functional aspects and strategies for their identification, purification, and characterization. In Ekman JSAR, editor. Mass spectrometry and hyphenated techniques in neuropeptide research. John Wiley Sons 2002. p. 11-45. 

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