Neuroimaging epilepsy

Abnormal Development and Catastrophic Epilepsies The Clinical Picture and Relation to Neuroimaging... 

Most studies of overall cell density have reported no significant change in schizophrenia (Dwork, 1997 Harrison, 1999 Arnold, 2000). Two studies provided estimates of total hippocampal cell number and found no changes in any of the four sectors of the cornu ammonis in schizophrenia (Heckers et al., 1991 Walker et al., 2002). The finding of normal total cell number is important for the interpretation of decreased hippocampal volume reported by neuroimaging studies of patients with schizophrenia. In contrast to neuropsychiatric disorder such as temporal lobe epilepsy and dementia, smaller hippocampal volume is not the macroscopic correlate of pyramidal cell loss in schizophrenia. 

Tae WS, Joo EY, Kim JH, Han SJ, Suh YL, Kim BT, Hong SC, Hong SB (2005) Cerebral perfusion changes in mesial temporal lobe epilepsy SPM analysis of ictal and interictal SPECT. Neuroimage 24 101-110. 

Epilepsy syndrome—The combination of seizure type with other components of the patient history such as age of onset, intellectual development, findings on neurologic examination, and results of neuroimaging. 

Williamson, P.D., French, J.A., and Thadani, V.M. Characteristics of medial temporallobe epilepsy II. Inter-ictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results and pathology. Ann. Neurol. 1993,34 781-787. 

Contributions of volumetric MRI and functional neuroimaging techniques are discussed below. These modahties have helped elucidate pathophysiological mechanisms of epilepsy, showing more widespread seizure-induced metabolic changes than previously appreciated. 

A. Ohenaus, Neuroimaging Biomarkers for Epilepsy Advances and Relevance to Glial Cells, Neurochem. Int, 2013, 63, 712. 

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