Neurogenesis and Alzheimers Disease

Alzheimer s disease is associated with the loss of nerve cells in areas of the brain, such as the hippocampus, that are vital to memory and other mental abilities (Hardy and Selkoe, 2002 St George-Hyslop and Petit, 2005). Hence, cognitive impairments that worsen over time are major disabilities of AD. Two classes of drugs are currently used to treat patients 

Reproduced from Taupin P. Neurogenesis and Alzheimer s Disease. Drug Target Insights (2006) 1 1-4, with permission from Libertas Academia. 

Arrieta, J.L., Artalejo, F.R. (1998). Methodology, results and quality of clinical trials of tacrine in the treatment of Alzheimer s disease a systematic review of the literature. Age Ageing, 27, 161-79. 

Cameron, H.A., McEwen, B.S., Gould, E. (1995). Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci, 15, 4687-92. 

Cameron, H.A., Tanapat, P., Gould, E. (1998). Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neurosci, 82,349-54. 

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