Neurobiology of depression

Procedures that have been suggested as models of depression and used to look for neurochemical changes that parallel the onset of the behavioural change, as well as to test how antidepressants affect the behaviour, are listed in Table 20.3. Those that have been used most, either as a drug screen or in research into the neurobiology of depression, are as follows. 

Manji HK, Drevets WC and Charney DS (2001). The cellular neurobiology of depression. 

Lopez, J. F., Chalmers, D. T., Little, K, Y. and Watson, S. J. A. E. Bennett Research Award. Regulation of serotonin 1 A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus implications for the neurobiology of depression. Biol. Psych. 43 547-573,1998. 

Source. Adapted from Delgado PL, Price LH, Miller HL, et al Rapid Serotonin Depletion as a Provocative Challenge Test for Patients With Major Depression Relevance to Antidepressant Action and the Neurobiology of Depression. Psychopharmacology Bulletin 27 321-330, 1991. Used with permission. 

Nestler EJ, Barrot M, DiLeone RJ, et al Neurobiology of depression. Neuron 34 13-25, 2002... 

Redrawn, with permission, from Nestler EJ Neurobiology of depression. Neuron 2002 34[l] 13-25.)... 

Maletic V et al Neurobiology of depression An integrated view of key findings. Int J Clin Pract 2007 61(12) 2030. [PMID 17944926]... 

Fibiger HC. Neurobiology of depression focus on dopamine. Adv. 53. Biochem. Psychopharmacol. 1995 49 1-17. 

Mackin P, Watson S, Ferrier N. The neurobiology of depression focus on cortisol, brain-derived neurotrophic factor, and their interactions. Depression Mind Body 2005 2 11-18. 

Delgado, P. L., Price, L. H., Miller, H. L., Salomon, R. M., Licinio, J., Krystal, J. H., Heninger, G. R., and Charney, D. S., Rapid serotonin depletion as a provocative challenge test for patients with major depression Relevance to antidepressant action and the neurobiology of depression, Psychopharmacol. Bull., TJ, 321, 1991. 

Nemeroff, Charles B. (1998). The Neurobiology of Depression. Scientific American 278 42 9. 

Nemeroff CB. Recent advances in the neurobiology of depression. Psychopharmacol Bull 2002 (Summer) 1 3 6. 

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