Neuraminidase inhibitors 1- pyrrolidin

G. T. Wang, Y. Chen, S. Wang, R. Gentles, T. Sowin, W. Kati, S. Muchmore, V. Giranda, K. Stewart, H. Sham, D. Kempf, and W. G. Laver, Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores, J. Med. Chem., 44 (2001) 1192-1201. 

Compounds derived from a cyclopentane or pyrrolidine skeleton have recently been attracting close attention as next-generation neuraminidase inhibitors [121,122,123,124,125], and active efforts have been made for screening of such compounds (O Scheme 18). Attempts have also been made to prevent virus infection by removing the tracheal sialic acid receptors (the starting point of viral infection) through direct inhalation of sialidase [126]. 

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