Nervous system headache, analgesics

Caffeine is used as a central nervous system (CNS) stimulant, anorexiant, diuretic, and in a number of analgesic and cold medication compounds. It is also used in the treatment of spinal headaches and has been used as a respiratory stimulant in preterm infants. 

Uncaria spp. have traditionally been widely used for the treatments of wounds, ulcers, fevers, headaches, and gastrointestinal illnesses [8,9]. Dried hooks of Uncaria spp. are used as major components of traditional medicines and have therapeutic applications as analgesics and sedatives for the nervous system-related disorders [8,9]. One of the important uses of Uncaria Spp. is their use in the treatment of hypertensirMi [12], Table 1 summarizes the list of ethno-medicinally important Uncaria species that are commonly used for the treatment of various diseases. 

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