Nerve function muscarinic cholinergic receptor

Responses are designated + to +++ to provide an approximate indication of the importance of sympathetic and parasympathetic nerve activity in the control of tiie various organs and functions listed. Adrenergic rec tors and subtypes thereof Cholinergic receptors nicotinic (N) muscarinic (M), with subtypes 1—4. The receptor subtypes are described more fully in Chapters 7... 

Tacrine has been found to be somewhat effective in patients with mild-to-moderate symptoms of this disease for improvement of cognitive functions. The drug is primarily a reversible cholinesterase inhibitor that increases the concentration of functional ACh in the brain. However, the pharmacology of tacrine is complex the drug also acts as a muscarinic receptor modulator in that it has partial agonistic activity, as well as weak antagonistic activity on muscarinic receptors in the CNS. In addition, tacrine appears to enhance the release of ACh from cholinergic nerves, and it may alter the concentrations of other neurotransmitters such as dopamine and NE. 

In the lung, many of the nonnal physiological processes that govern airway function are mediated by muscarinic receptors. Cholinergic nerves in the vagi regulate airway tone and reactivity. These nerves release ACh onto M3 muscarinic... 

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