Nerve agents subcutaneous exposure

The inhibition of AChE activity in nerve tissues of animals at different times after exposure to low-dose nerve agents are depicted in Table 3.3. In most studies, subcutaneous, intravenous, inhalation, and oral routes of exposure were used. AChE activity in whole brain, spinal cord, and brain regions such as cerebral cortex, corpus striatum, meduUa, and cerebellum was significantly decreased in rats, " " mice, and hens, ° hours, days, and weeks after low-dose exposure to nerve agents such as soman, sarin, and tabun. 

The inhibition of cholinesterase in peripheral tissues of animals exposed to low dose nerve agents at different time points is summarized in Table 3.4. In most of the studies, subcutaneous, intramuscular, inhalation, as well as oral routes of exposure were employed. Cholinesterase activity in whole blood and blood constituents, such as plasma, RBC, and platelets, was significantly depressed in humans," mon-keys, rats, mice, and hens hours and days foUowmg... 

---