Nerve agents interaction Tabun

Somani and Husain described the low-dose toxicity of tabun, sarin, soman, and VX under normal as well as stressful conditions. These authors explained the interaction of enviromnental and physical stress on cholinergic as well as noncholinergic effects induced by low-dose exposure to nerve agents and their potential for additive or synergistic neuropathologic sequelae. Under certain conditions, nerve agents may... 

H]L-PIA) to the brain membranes in a dose-dependent manner. Soman was fonnd to be five and nine times more effective than tabun and sarin, respectively, in inhibiting [ H]L-PIA binding. They snggested that nerve agents could interact directly at the A1 adenosine receptors, which could subsequently mediate changes in permeability of the synaptic membrane, with possible effects on Na and/or Ca conductance. 

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