Nerve agents interactions

The last chapter by Michalkova et al. presents a review of the experimental and theoretical data on nerve agent interactions with different surfaces. Particular attention is given to molecular simulations of interaction and decomposition of phosphoroorganic compounds on various metal and metal oxide clusters. 

Interactions of Nerve Agents with Clay Minerals... 

Interactions of Nerve Agents and Their Simulants with Metal Oxides... 

E. Elhanany, A. Ordentlich, O. Dgany, D. Kaplan, Y. Segall, R. Barak, B. Velan and A. Shafferman, Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases MALDI-TOF/MS analysis of various nerve agent phosphyl adducts, Chem. Res. Toxicol., 14, 912-918 (2001). 

AH of the nerve agents under consideration are anticholinesterase compounds and induce accumulation of the neurotransmitter acetylcholine (ACh) at neural synapses and neuromuscular junctions by phosphorylating acetylcholinesterase (AChE). Depending on the route of exposure and amount absorbed, the PNS and/or CNS can be affected and muscarinic and/or nicotinic receptors may be stimulated. Interaction with other esterases may also occur, and direct effects to the nervous system have been observed. 

Beck, J.M., Hadad, C.M. (2008). Hydrolysis of nerve agents by model nucleophiles a computational study. Chem. Biol. Interact. May 2. (Epub ahead of print)... 

Bajgar, J., Hajek, P., Slizova, D., Krs, O., Fusek, J., Kuca, K., Jun, D., Bartosova, L., Blaha, V. (2007). Changes of acetylcholinesterase activity in different rat hrain areas following intoxication with nerve agents biochemical and histochemical study. Chem. Biol. Interact. 165 14-21. 

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