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Nerve agents excitotoxicity

Solberg, Y., Belkin, M. (1997). The role of excitotoxicity in organophosphorous nerve agents central poisoning. Trends Pharmacol. Sci. 18 183-5. [Pg.479]

Among promising candidates as antidotes against CNS intoxication by OP nerve agents, memantine (MEM) has been shown to pose both anti-excitotoxic and anti-epileptic properties. Memantine is an uncompetitive NMDA receptor antagonist, clinically used for the treatment of Alzheimer s disease, Parkinson s disease and spasticity, in the absence of serious side effects (Ozsuer et al, 2005 Lipton, 2005). From a series of rat in vivo experiments, it is evident that pre-administration of memantine significantly protects... [Pg.644]

See other pages where Nerve agents excitotoxicity is mentioned: [Pg.474]    [Pg.486]    [Pg.527]    [Pg.634]    [Pg.634]    [Pg.635]    [Pg.644]    [Pg.645]    [Pg.654]    [Pg.654]    [Pg.655]    [Pg.655]    [Pg.655]    [Pg.659]    [Pg.146]    [Pg.332]    [Pg.482]    [Pg.595]    [Pg.709]    [Pg.719]    [Pg.721]    [Pg.742]    [Pg.743]    [Pg.743]    [Pg.744]    [Pg.747]    [Pg.232]    [Pg.665]    [Pg.665]    [Pg.193]    [Pg.454]    [Pg.50]   
See also in sourсe #XX -- [ Pg.654 ]



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