Nephrectomy model

Stockelman et al. (1998) described chronic renal failure in a mouse model of human adenine phospho-ribo-syltransferase deficiency. Hamilton and Cotes (1994) used a partial nephrectomy model in mice with two-thirds of the total renal mass excised to evaluate erythropoiesis and erythropoietin production from extrarenal sources such as the submandibulary salivary gland. Koumegawa et al. (1991) suggested the DBA/2FG-pcy mouse, which develops numerous cysts in kidney cortex and medulla, a progressive anemia and an elevation of blood urea nitrogen, as a useful spontaneous model of progressive renal failure. 

Ramakumar S, Phull H, et al. (2005). Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. J. Urol. 174 1133-1136. 

In animal models of acute renal failure induced in rats by bilateral nephrectomy and bilateral ureteral ligation, TAC increased, probably due to the accumulation of urate and uremic toxins with scavenging capacity, such as hyppurate (B19, S9). TAC of blood plasma was reduced in a rat endotoxic shock model (rats given i.p. 5 mg/kg lipopolysaccharide) (Cl6). 

Subtotal (five-sixths) nephrectomy in rats has been used by many authors as model for chronic renal failure. Levine et al. (1997) used this model to evalu-... 

Kimura et al. (1999) reported a model of progressive chronic renal failure in rats, produced by a single injection of microspheres (20 to 30 pM in diameter) into the left renal artery after right nephrectomy. 

Castilho et al. (1990) studied the intestinal mucosal cholesterol synthesis in rats using a chronic bile duct-ureter fistula model. Male Wistar rats weighing 300-350 g were anesthetized with 50 mg/kg pentobarbital i.p. and submitted to a bile duct-right ureter fistula utilizing a PE-50 catheter after a right-kidney nephrectomy. 

Morroquin et al. [44] studied the effect of high-dose IL-2 therapy in the treatment of patients with metastatic melanoma and renal cell cancer. Animal models have shown that successful treatment with IL-2 is dose and schedule dependent. They found that there was a subset of patients who could not tolerate high doses or retreatment due to renal toxicity. Pretreatment factors that were significantly associated with renal toxicity were male sex, diagnosis of renal cancer, previous nephrectomy, and older age. These patients also had higher baseline creatinine. 

Fernandez A, et al. First prize a phantom model as a teaching modality for laparoscopic partial nephrectomy. J Endourol 2012 26(l) l-5. 

McNeil DE, Brown M, Ching A et al (2001) Screening for Wilms tumor and hepatoblastoma in children with Beckwith-Wiedemann syndromes a cost-effective model. Med Pediatr Oncol 37(4) 349-356 McNeil DE, Danger JC, Choyke P et al (2002) Feasibility of partial nephrectomy for Wilms tumor in children with Beckwith-Wiedemann syndrome who have been... 

Sehr et al (1977) have used P NMR to study certain problems related to kidney transplantation. A major problem in human kidney transplant surgery is tissue preservation. The two major factors determining graft viability after transplantation are the condition of the donor immediately prior to cadaveric nephrectomy and the time that the kidney spends at body temperature without circulation before its removal, when it is placed on ice and transplanted within the next 24 hr. The assessment of tissue viability and ways of prolonging preservation are important goals of renal research. In this study P NMR was used as a continuous monitor of renal energy status in an experimental animal model in which the blood of a control rat was used to perfuse an excised kidney from a second rat. 

---