Neonatal Administration

Eroschenko VP, Mousa MA. 1979. Neonatal administration of insecticide chlordecone and its effects on the development of the reproductive tract in the female mouse. Toxicol Appl Pharmacol 49 151-159. 

There are indications that early exposure to lead decreases acetylcholine release and turnover (ref. 101). In addition, neonatal administration of lead has been shown to increase the number of GABAergic receptors at the age of 60-70 days (ref. 14). Effects of early lead exposure on dopamine and noradrenaline levels may also exist (ref. 102). 

S.E. File, The effects of neonatal administration of clonazepam on passive avoidance and on social, aggressive and exploratory behavior of adolescent male rats, Neurobehav. Toxicol. Teratol., 8(5) (1986) 447-452. 

A.J. Kastin, R.M. Kostrzewa, A.V. Schally and D.H. Coy, Neonatal administration of Met-enkephalin facilitates maze performance of adult rats, Pharmacol. Biochem. Behav., 13(6) (1980) 883-886. 

Interestingly, neonatal administration of the drug induced tolerance but not immunopathological manifestations [137]. The tolerance to HgCl2-induced autoimmunity was transferable by CDS (CD25 ) spleen... 

Mokler DA, Robinson SE, Johnson JH, Hong JS, Rosecrana JA (1987) Neonatal administration of A -tetrahydrocannabinol alters the neurochemical response to stress in the adult Fischer-344 rat. Neurotoxicol Teratol 9 321-326... 

Sakaguchi S Sakaguchi N (1989) Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J Immunol, 142(2) 471-480. 

F.M. Poulet, P.M. Vancutsem, and G.D. Bellward (1999). Modulation of hepatic CYP2A1, CYP2C11, and CYP3A9 expression in adult rats by neonatal administration of tamoxifen. Drug Metab. Dispos. 27, 1392-1398. 

Sakaguchi, S., and Sakaguchi, N. (1989) Organ-Specific Autoimmune Disease Induced in Mice by Elimination of T Cell Subsets. V. Neonatal Administration of Cyclosporin a Causes Autoimmune Disease, J. Immunol. 142,471 80. 

Cuello, A. C., Gamse, R., Holzer, P., and Lembeck, F., 1981, Substance P immunoreactive neurons following neonatal administration of capsaicin, Naunyn-Schmiedeberg s Arch. Pharmacol. 315 185-194. 

Neonatal administration of HgCl2 to BN rats does not trigger the disease, protects adult rats from rechallenge to mercury, but does not modify the course of the disease induced by gold salts in adult rats (Pillion et al., in preparation). This suggests that HgCl2 is able to specifically render animals tolerant to Hg-induced immune disorders. 

Isolation of such chains is greatly facilitated if the immunoglobulin is derived from rabbits in which the synthesis of molecules bearing b locus markers had been suppressed (Section V) by neonatal administration of antibodies directed to 6-locus determinants. 

Russell, D.H., Mills, K.T., Talamantes, F.J. and Bern, H.A. (1988) Neonatal administration of prolactin antiserum alters the developmental pattern of T- and B-lymphocytes in the thymus and spleen of BALB/c female mice. Proc. Nat I. Acad. Sci. USA, 85, 7404-7407. 

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