Neoglycolipids in anticancer treatments

The vaccine was incorporated into phospholipid-based liposomes prior to administration the mice that were immunized with the liposome preparations elicited IgM and IgG antibodies against the Tn antigen. 

Synthesis of the vaccine candidate 21 was achieved in high yield by condensation of the C-terminal carboxylic acid of lipopolypeptide (24) and the amine of spacer-containing Tn antigen (25), followed by deprotection of the amino acid side chain. The fully protected lipopolypeptide 24 was produced by coupling the lipid S-[2,3-bis(hexadecanoyloxy)-propyl]-7V-Fmoc-Cys (Pam2FmocCys (3)) to the N-terminal amine of the resin-bound peptide (22), and by subsequent linking of the hexadecanoic add to the free amine of the resin-bound lipopolypeptide (Fig. 14). 

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