Neocarcinostatine chromophore

Neocarcinostatin chromophore model Intramol. HR of an alkenyl bromide [175]... 

The cytotoxic neocarzinostatin (NCS) is a small protein (Mw 12 kD) associated with a low molecular weight chromophore. NCS is rapidly cleared by the kidney and its cytotoxicity is non-cell specific. To modify its disposition, two poly(styrene-co-maleic acid anhydride) copolymers (Mw 1,500) have been coupled to one molecule of NCS, to give styrene-maleic-anhydride-neocarcinostatin (SMANCS) systems. 

Neocarzinostatin, a polypeptide antibiotic from Streptomyces carzinostaticus with strong anticancer activity. Neocarcinostatin consists of an enediyne chromophore non-covalently associated to a peptide chain with 113 residues (Mr 10.7 kDa). Neocarzinostatin has potential importance for the therapy of leukemia and both stomach and pancreatic cancer [A. L. Smith, K. C. Nicolaou, J. Med. Chem. 1996, 39, 2103]. 

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