Neocalliactine acetate, synthesis

The same strategy has been applied to the preparation of a number of pyridoacridine alkaloids, which include 2-bromoleptoclinidone 29 (90LA205), 11-hydroxyascididemin 30 (93H943) and kuanoniamine A 146 (93H943), and also for the synthesis of neocalliactine acetate 139 (92LA1205 93H943) (a derivative of calliactine 32). 

Synthesis of neocalliactine acetate (366), which was achieved by Kubo et al. in 1993, proved that the structures of neocalliactine acetate and calliactine are indeed 366 and 364, respectively (157). 

Bracher, F. (1992) The structure of neocalliactine acetate proof by total synthesis. Liebigs Arm. Chem., 1205-1207. 

Kitahara, Y Nakahara, S., Yonezawa, T., Nagatsn, M., and Kubo, A. (1993) Total synthesis of kuanoniatnine-A, ll-hydroxyasddidemin, and neocalliactine acetate. Heterocycles, 36,943-946. 

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