Neo-Mercazole

Proprietary Names. Carbazole Carbotiroid Neo-Mercazole Neo-Morphazole Neo-Thyreostat Neo-Tireol. 

Neo-Mercazole carbimazole. neomycin [ban, inn] (neomycin suiphate Mycifradin ) is an (aminoglycoside) ANTIBIOTIC composed of a complex of neomycin A, B and C - early members of the aminoglycoside family produced by the mould Streptomyces fradiae. It has broad-spectrum antibacterial properties but is too toxic to be injected, though it can be used in treating some superficial bacterial infections, and is occasionally taken by mouth to reduce the levels of bacteria in the gut (it is not absorbed), neomycin B framycetin sulphate, neomycin sulphate neomycin, neopentanetetrayl nicotinate niceritrol. Neoral cyclosporine. 

The antithyroid compounds currently used in the United States are propylthiouracil (6- -propylthiouracil) and methimazole (/-methyl-2-mercaptoimidazole Tapazole). In Great Britain and Europe, carbimazole (Neo-mercazole), a carbethoxy derivative of methimazole, is available, and its antithyroid action is due to its conversion to methimazole after absorption. Measurements of the course of organification of radioactive iodine by the thyroid show that absorption of effective amounts of propylthiouracil follows within 20 to 30 minutes of an oral dose, and that the duration of action of the compounds used clinically is brief. The effect of a dose of 100 mg of propylthiouracil begins to wane in 2 to 3 hours, and even a 500-mg dose is completely inhibitory for only 6 to 8 hours. As little as 0.5 mg of methimazole similarly decreases the organification of radioactive iodine in the thyroid gland, but a single dose of 10 to 25 mg is needed to extend the inhibition to 24 hours. 

Carbimazole. 2,3-Dihydro-3-mrthyi-2-thioxo-lH-imidazole-l-carboxylic acid ethyl ester, l-ethoxycarbonyl-3-methyl -2-thio-4-imidazoline ethyl 3 -methyl -2 -thioimid azoline-1 -carboxylate 1 -methyl -3-carbethoxy-2-thiogly-oxalone athyromazole Neo-mercazole Neo-Thyreostat. C,H10N2OjS mol wt 186.23. C 45.15%, H 5.417=, N 15,047=., O 17.187=, S 17.22%. Prepn RimingtOn et al,... 

Methimazole, 2-mercapto-l-methyl-imidazole, useful in thyrotoxicosis, is usually given as the 2-ethoxycarbonyl-derivative (3.44) (carbimazole, Neo-Mercazole ) which forms a depot. 

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