Neisseria species, inhibition

Antibacterial Spectrum. Hawley reported that various species and strains of the genera Staphylococcus, Streptococcus, Neisseria, Bacillus, Clostridium, and Corynebacterium are inhibited by nisin (Hawley 1957A, B). Mattick and Hirsch (1947) added actinomycetes, pneumococci, mycobacteria, and Erysipelothrix to this list. The nisin concentration required for complete inhibition is organism specific and ranges from 0.25 to 500 units per milliliter. Inhibition of L. casei by antibiotics from S. lactis and S. cremoris was observed by Baribo and Foster (1951). Inhibition of Propionibacterium by nisin but not of coliform bacteria was reported by Galesloot (1957). 

The susceptibility of almost all strains of various species of Neisseria (gonorrhoeae, meningitidis, flava) to in vitro inhibition by acetazolamide (2-acetamino-l,3, thiadiazole-5-sulfonamide) is unique relative to other organisms,90 91 but apparently does not carry over to in vivo infections. Inhibition of only N. gon. occturred at high CO2 concentrations the other N. and resistant bacteria appear to have low concentrations of carbonic anhy-drase.90... 

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