Neisseria gonorrhoeae with Chlamydia trachomatis

Stamm WE, Guinan ME, Johnson C, Starcher T, Hohnes KK, McCormack WM. Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. N Engl J Med 1984 310 545-9. 

Acute salpingitis (pelvic inflammatory disease) due to Neisseria gonorrhoeae. Chlamydia trachomatis, or both is often complicated by superinfection with gramnegative bacilli and anaerobes. A combination of gentamicin, clindamycin, and doxycycline has been shown to be an effective treatment for this polymicrobial infection. 

Coexistent infection. Chlamydia trachomatis is frequently present with Neisseria gonorrhoeae tetracycline by mouth for 7 days or a single oral dose of azithromycin Ig will treat the chlamydial urethritis. 

Several pathogens are involved including Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma hominis and there may be superinfection with bowel and other urogenital tract bacteria. A combination of antimicrobials is usually required, e.g. metronidazole plus doxycycline by mouth. 

Buimer M, van Doornum GJ, Ching S, Peerbooms PG, Plier PK, Ram D, et al. Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by ligase chain reaction-based assays with clinical specimens from various sites implications for diagnostic testing and screening, J Clin Microbiol 1996 34 2395-400. 

Some of the most serious sequelae of STDs are associated with congenital or perinatal infections. Most neonatal infections are acquired at birth, after infant passage through an infected cervix or vagina. Neonatal Chlamydia trachomatis, Neisseria gonorrhoeae, and herpes simplex virus (HSV) infections are associated with this type of spread. For pregnant women with syphilis, infection is usu-... 

Lyss SB, Kamb ML, Peterman TA, et al. Chlamydia trachomatis among patients infected with and treated for Neisseria gonorrhoeae in sexually transmitted disease clinics in the United States. Ann Intern Med 2003 139 178-185. 

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