Nebulizer breath activated

Q7 Outline the advantages of using a nebulizer rather than a breath-activated or dry-powder inhaler. Would you expect this medication to fully reverse Mandy s bronchoconstriction ... 

Smaldone, G.C. Enhanced In-Vitro Delivery of Budesonide via Continuous and Breath-Activated Nebulization, European Respiratory Society, Florence Italy, Aug 30-Sept 3, 2000. 

Hanania NA, Wittman R, Kesten S, Chapman KR. Medical personnel s knowledge of and ability to use inhaling devices metered dose inhalers, spacing chambers, and breath-activated dry powder inhalers. Am Rev Respir Dis 1993 147 SSA983. Kelling JS, Strohl KP, Smith RL, Altose MD. Physician knowledge in use of canister nebulizers. Chest 1983 83 612-614. 

Aerosolized medications are available as pressurized or breath-actuated metered-dose inhalers (MDIs), dry powder inhalers (DPIs), and nebulized or wet aerosols. Most inhaled medications currently used are available as metered-dose inhalers (Table 3). For the patient who has difficulty to coordinate activation of a MDI, a spacer improves delivery. Spacers reduce deposition of the drug in the... 

Jet nebulizer (small volume) Volume fill (3-6 mL) Gas flow (6-12 L/min) Dead-space volume Open versus closed system Thumb-activating valve Mouthpiece versus facemask Inspiratory flow (slow, deep) Breath-holding Tapping nebulizer... 

Inhalation scintigraphy 150 MBq (4 mCi) inhaled radioactivity (nebulized activity 1,110 MBq resp., 30 mCi). Breathing time 3-5 min, with an oxygen supply of 7-10 1/min... 

Vidgren and co-workers (219) studied six normal volunteers who inhaled 20 breaths of beclomethasone dipropionate liposomes labeled with technetium in the presence of SnCU as a reducing agent. Particles were inhaled from each of two nebulizers Aerotech II nebulizer and Spira nebulizer. Pulmonary deposition was 17 7% for Aerotech II and 14 3% for Spira nebulizer. At 3 hr, 93% of the deposited activity was detected in the volunteers breathing from the... 

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