NDRIs

MAOI, monoamine oxidase inhibitor NaSSA, noradrenergic and specific serotonergic antidepressant NDRI, norepinephrine and dopamine reuptake inhibitor SARI, serotonin antagonist and reuptake inhibitor SNRI, serotonin and norepinephrine reuptake inhibitor SSRI, selective serotonin reuptake inhibitor TCA, tricyclic antidepressant. 

Different types of antidepressants are supposed to work by different means. SSRIs (selective serotonin reuptake inhibitors) are supposed to increase serotonin levels. NDRIs (norepinephrine dopamine reuptake inhibitors) are supposed to increase norepinephrine and dopamine, rather than serotonin. These two types of antidepressants are supposed to be selective , affecting the... 

Andrea Cipriani et al., 2009. The calculations are simple and straightforward. Table 3 of The Lancet article reports response rates for head-to-head comparisons of different antidepressants, along with the number of subjects on which each response rate was based. I merely extracted the response rates in all of the head-to-head comparisons of an SSRI with an NDRI, multiplied each response rate by the number of subjects it was based on, summed the product and divided... 

Although there seems to be no doubt that Six William Crookes was the first to observe the green line of thallium, many chemical historians, especially the French ones, attribute the isolation of the metal itself to Claude-Auguste Lamy. He was bom on July 15, 1820, at Ndry in the Jura department of France, attended the ficole Normale Supdrieure in Paris, and at the age of thirty-one years received his doctorate from Lille, He taught physics, first at Limoges and later at Lille (16). 

FIGURE 6-48. Shown here is the icon of a norepinephrine and dopamine reuptake inhibitor (NDRI). In this case, four of the five pharmacological properties of the tricyclic antidepressants (TCAs) (Fig. 6—27) were removed. Only the norepinephrine reuptake inhibitor (NRI) portion remains to this is added a dopamine reuptake inhibitor action (ORI). 

FIGURE 6—49- In this diagram, the norepinephrine reuptake inhibitor (NRI) and the dopamine reuptake inhibitor (DRI) portions of the NDRI molecule are shown inserted in the norepinephrine and the dopamine reuptake pumps, respectively, blocking them and causing an antidepressant effect. 

FIGURE 7-46. Heroic combo 2 High-dose venlafaxine plus NDRI (bupropion). Here, 5HT is single-boosted, NE is double-boosted, and DA is double-boosted. 

FIGURE 7-55. Heroic combo 11 SSRI plus NDRI (bupropion). Here 5HT, NE, and DA are all single-boosted. 

FIGURE 7—57. Heroic combo 13 Nefazodone plus NDRI (bupropion). In this case, the serotonergic single boost of nefazodone is added to the NE and DA single boost of bupropion. 

NDRi (norepinephrine dopamine reuptake inhibitor) antidepressant smoking cessation treatment... 

---