Nausea ranolazine

The most common adverse effects are dizziness, headache, constipation, and nausea. Ranolazine should be started at 500 mg twice daily and increased to 1,000 mg twice daily if needed based on symptoms. Baseline and followup ECGs should be obtained to evaluate effects on the QT interval. 

Ranolazine Inhibits late sodium current in heart also may modify fatty acid oxidation Reduces cardiac oxygen demand fatty acid oxidation modification may improve efficiency of cardiac oxygen utilization Prophylaxis of angina Oral, duration 6-8 h Toxicity QT interval prolongation, nausea, constipation, dizziness Interactions Inhibitors of CYP3A increase ranolazine concentration and duration of action... 

Ketoconazole. In a double-blind, randomised study, healthy subjects were given slow-release ranolazine 375 mg twice daily for 9 days, with ketoconazole 200 mg twice daily on days 5 to 9. The same study was repeated with ranolazine 1 g twice daily. It was found that ketoconazole increased the AUC, levels (mean, peak and trough) and half-life of ranolazine by 2.5- to 4.5-fold. The most common adverse events were headaches, dizziness and nausea. In some patients the higher dose of ranolazine with ketoconazole resulted in intolerable adverse events. ... 

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