Nausea levofloxacin

Fluoroquinolones are extremely well tolerated. The most common effects are nausea, vomiting, and diarrhea. Occasionally, headache, dizziness, insomnia, skin rash, or abnormal liver function tests develop. Photosensitivity has been reported with lomefloxacin and pefloxacin. QTC prolongation may occur with gatifloxacin, levofloxacin, gemifloxacin, and moxifloxacin, which should be avoided or used with caution in patients with known QTC interval prolongation or uncorrected... 

The adverse effects rates of levofloxacin are 1.3% for nausea, 0.1% for anxiety, 0.3% for insomnia, and 0.1% for headache. No levofloxacin-related adverse events were reported at a rate higher than 1.3%, and most were less common. High-dose levofloxacin (750 mg) was also well tolerated. Surveillance data reported low adverse event rates nausea 0.8%, rash 0.5%, abdominal pain 0.4%, and diarrhea, dizziness, and vomiting 0.3%. The adverse drug reactions rate for levofloxacin is stiU one of the lowest of any fluoroquinolone, at 2% compared with 2-10% for other fluoroquinolones (6-9). 

Comparative studies Oral moxifloxacin for 2 weeks has been compared with levofloxacin -I- metronidazole in 460 women with uncomplicated pelvic inflammatory disease [41 ]. Clinical and bacteriological efficacies were comparable nausea (19% and 23%) and dizziness (16% and 15%) in the moxifloxacin and comparator groups were the most common adverse events. One moxifloxacin-treated subject developed Stevens—Johnson syndrome. 

Comparative studies In a prospective, double-blind, non-inferiority phase 3 trial of tigecycline versus levofloxacin for community-acquired pneumonia, the following adverse events were reported in 212 patients who took levofloxacin headache in four (1.9%) hypokalemia in eight (3.8%) leukocytosis and thrombocythemia in two and four (0.9% and 1.9%) diarrhea, nausea, and vomiting in 17, 18, and 14 (8, 8.5, and 6.6) and raised aminotransferase activities in 16 (7.5%) [58 ]. 

In a phase 3 comparison study of intravenous levofloxacin with intravenous tige-cychne, the following adverse events were reported in 210 patients who took levofloxacin headache in 10 (4.8%) diarrhea, nausea, and vomiting in 9, 12, and 4 (4.3%, 5.7%, and 1.9%) anemia and eosinophilia in 7 and 11 (3.3% and 5.2%) raised aminotransferase activities in 21 (10%) and raised alkaline phosphatase activity in 3.8%. [59 ]. 

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