Naturally Occurring Vanadium Compounds

Applications to specific biological systems containing vanadium will be addressed in some detail in the context of the respective subsections of Chapter 4 on naturally occurring vanadium compounds vanadium in sea squirts (e.g. Figure 4.3), vanadate-dependent haloperoxidases (e.g. Table 4.5) and vanadium nitrogenases (e.g. Table 4.8). The central messages, including key references, are briefly summarised here. 

Naturally Occurring Vanadium Compounds 4.3.3.1 Structural Models of Reduced Haloperoxidases... 

The first structural elucidation of a naturally occurring vanadium compound has been achieved. Amavadine, which has been isolated from the fly Amanita muscaria, has been shown by degradative, synthetic, and spectroscopic studies to have the structure (32) (p.54). The use of the vanadyl group as a new spectroscopic probe of metal binding sites in proteins has been demonstrated by its incorporation into insulin. E.s.r., optical, and i.r. spectra of the protein-bound have indicated that it is held on two types of site the co-ordination geometry about the metal was determined in each case. This approach should be valuable in the study of other metalloproteins. ... 

H. Kneifel and E. Bayer, Stereochemistry and total synthesis of amavadin, the naturally occuring vanadium compound of kmanltd mu6CaKla, J.Am.Chem.Soc. 108 (1986) 3075-3077. 

Kneifel, H., and E. Bayer Stereochemistry and Total Synthesis of Amavadin, the Naturally Occurring Vanadium Compound of Amanita muscaria. J. Amer. Chem. Soc. 108, 3075 (1986). 

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