Natural History of HAD

Stage 0 (iionnal) Nonnal mental and motor function 

Stage 0.5 (equivocaP Absent, muiimal, or equivocal symptoms witliout 

Stage 2 (moderate) Able to perform basic aedvides of self-care but can not work or maintam die more demandmg aspects of daily hfe. Ambulatory, but may requhe a suigle prop 

000 copies/mL at baseline had 8.5 dmes higher chance of developing demen da as compared with those with less than 

Inidal estimates on the prevalence of HAD were as high as 66%, but more recently reported at 7% (Navia and Price, 1987 Janssen et al., 1992). With the widespread use of potent, com-binadon ART, the overall incidence of HAD has decreased dramadcally. For example, the incidence of newly diagnosed moderate-to-severe demenda fell from 6.6% in 1989, to 1% in 2000 (McArthur et al., 2003). In addidon, the mean CD4 T cell count for padents with HAD has progressively increased with access to improved ART. A study by the Nadonal Cend e in HTV Epidemiology and Clinical Research at the University 

Stage 0 (normal) Normal mental and motor function 

Stage 0.5 (equivocal/ Absent, minimal, or equivocal symptoms without 

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