Natural and synthetic biologically-active

Chiral non-racemic cyclopropanes are a common motif in natural and synthetic biologically active compounds [85]. They represent an important target in asymmetric synthesis, and a range of catalytic methods have been developed for their synthesis [6, 47, 86-90]. Many of the existing methods make use of a chiral metal complex as catalyst [6], but organocatalytic methods have also been developed. In this section we will review methods using a substoichiometric amount of a chiral ylide as a catalyst for cyclopropanation [91]. 

ACID-TREATMENT OF ARYLPROPANOID AND ARYLETHANOID DERIVATIVES - ACCESS TO NATURAL AND SYNTHETIC BIOLOGICALLY ACTIVE POLYPHENOLS... 

The test set comprises 20 structures of highly, medium and low effective natural and synthetic biologically active substances characterized by high structural similarity of the training set structures of the Ml model (See Table 20.2). 

The test selection comprises 21 stmctures of high-, medium- and low active natural and synthetic biologically active characterized by close structural similarity to structures of the training set of models Ml and M2 [3], The typical structures in the training set of Ml and M2 models included compounds and their corresponding IC values are presented in Table 21.1. 

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