Narrow genetic base

In Chenopodium strictum there seems to be no fitness difference between resistant and susceptible individuals (9). C. strictum is a very slow-growing species and it is unlikely that photosynthetic electron transport limits its growth. Other cases are more complicated and may be due to various interrelated functions (a) fitness was not measured from germination on (b) there may be density dependent functions (c) there may be different reactions to environmental conditions (d) there may be different germination characters and seed bank dormancies (e) the narrow genetic base of resistant individuals (28-30) is probably detrimental compared to the broad base in the susceptible wild type. 

Drugs, among all the environmental factors that we are exposed to, may be particularly likely to interact specifically and selectively with the genetic properties of a given individual, as their potency pitches them into a narrow therapeutic window , precariously balanced between potent potions and perilous poisons. We would predict that, based on a patients innate, individual biological makeup -as it affects the interaction with a drug - one or the other of these properties may manifest itself this phenomenon is covered by the term pharmacogenetics. 

---