Narcissus lectin

Narcissus lectin (agglutinin) Narcissus pseudonarcissus ce-O-Mannoside... 

Lectins The mannose-specific plant lectins from Galanthus, Hippeastrum, Narcissus, Epipactis helleborine, and Listera ovata, and the V-acctylglucosaminc-spccilic lectin from Urtica dioica would primarily be targeted at the virus-cell fusion process. 

A number of mannose-specific agglutinines (lectins) from Galanthus nivalis, Hippeastrum hybrid, Narcissus pseudonarcissus, Listera ovata, Cymbidium hybrid, Epipactis helleborine, and the N-acetylglucosamine-specific lectin from Urtica dioica have been found to inhibit HIV-1 and HIV-2 infection at similar concentrations as dextran sulfate (IC50 0.2 to 0.6 fig/ml), or even lower (IC50 0.04 to 0.08 pg/ml. Akin to sulfated polysaccharides, the plant lectins also exhibit activity against various enveloped viruses other than HIV, i.e., HSV-1, HSV-2, CMV, RSV, and influenza virus. Plant lectins would primarily interfere with the virus-cell fusion process. Their precise mode of action remains to be resolved. 

C. Anti-human immunodeficienqf virus type 1 (HIV-1) activity of lectins from Narcissus species. Planta Med. 2003, 69, 109—112... 

The alkaloids from the genus Narcissus are the compounds responsible for the majority of the above-mentioned activities, although the mannosa-binding lectins have also received much interest recently (430-435). 

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