Naproxen nephrotoxicity

However, it is important to note that the addition of nephrotoxic agents, such as amphotericin B, aminoglysides (e.g., gentamicin, tobramidn, or amikacin), and non-steroidal anti-inflammatory drugs (NSAIDs e.g., naproxen, ibuprofen, or ketorolac) may potentiate the nephrotoxic effects of the calcineurin inhibitors. 

NSAIDs have an overall favorable safety profile resulting in OTC availability in the United States of ibuprofen, naproxen, and keto-profen for short-term therapy. WWle potential adverse renal effects from OTC NSAIDs have been a concern, activity of vasodilatory prostaglandins is not necessary to maintain renal function in healthy individuals. NSAIDs are unlikely to impair renal function in the absence of renal ischemia or excess renal vasoconstrictor activity. Nevertheless, given the fact that 50 million U.S. citizens report NSAID use, it has been estimated that 500,000 to 2.5 million people will develop NSAID nephrotoxicity in this country annually. ... 

Naproxen sodium Anaprox, Aleve, Naprelan Oxaprozin Daypro Piroxicam Feldene Sulindac Clinoril Tolmetin sodium Tolectin Adverse reactions Abdominal pain, bleeding, anorexia, ulcers, liver toxicity, dyspepsia, heartburn (minimized if taken with meals) flank pain may indicate nephrotoxicity drowsiness, headache, dizziness, confusion, tinnitus, vertigo, depression, bladder infections, blood in urine and kidney necrosis... 

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