Naproxen-lactic acid-lysozyme

An example is provided by the renal delivery of naproxen coupled to lysozyme via an L-lactic acid spacer [261b]. Here, the terminal amino group... 

E. J. F. Franssen, F. Moolenaar, D. De Zeeuw, and D. K. F. Meijer, Low molecular weight proteins as carriers for renal drug targeting Naproxen coupled to lysozyme via the spacer L-lactic acid, Pharm. Res. 70 963-969 (1993). 

The protein-polymer microcapsules can be obtained by supercritical anti-solvent techniques [8]. Homogeneous protein-polymer mixtures were contacted with supercritical carbon dioxide in order to produce microspheres with diameter ranging from 1 to 5 pm and containing around 80% of protein. Production of PLA microparticles containing insulin, lysozyme, and chemotrypsin is claimed. SAS crystallization of a pharmaceutical (naproxen) and a biodegradable poly(L-lactic acid) was reported [8]. The results from SAS studies showed very small spherical particles... 

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