Naphthyl amine hydrochloride

Diazoaminonaphthalene [called l,l -(or a,a -) Diazoaminonaphthalin or 1,3-Di-a-naphthyl-triazen-(l) in GerJ.CioHy.NrN.NH.CioH mw 297.34, N 14.13% yel-bm pits (from ale), mp - melts to a resin at water-bath temp, explodes on heating to a higher temp (ca 100 was obtd by action of a dil ale soln of NaN02 on a-naphthyl-amine hydrochloride Refs 1) Beil 16, 716 2) Sax(1957), 716... 

Condensation of an o-nitrosophenol with an amine hydrochloride in acetic acid (10) Nile Blue [2381-85-3] is formed from the hydrochloride of 1-naphthyl amine. 

E)-N-methyl-N-(l-naphthyl methyl)-3-phenyl -2-propen-l-amine hydrochloride... 

Acetaldehyde added with cooling to a mixture of 2-hydroxybenzal-2-naphthyl-amine, some 2-naphthylamine hydrochloride, and alcohol, then heated in a sealed tube for 1-3 hrs. in a boiling water bath 2-(2-hydroxyphenyl)-5,6-benzoquinoline. Y 50.0%. F. e. s. N. S. Kozlov and I. A. Shur, 7K. 29, 3779 (1959) G. A. 54, 19677c. 

A colorimetric method for the determination of materials containing a primary aromatic amine (such as benzocaine) is based upon diazotisation and coupling with iV-(l-naphthyl)ethylenediamine hydrochloride. It has been adapted for assay of benzocaine, procaine hydrochloride, butacaine... 

Water-soluble bases are not precipitated on making alkaline some aromatic amines such as the nitroanilines dissolve in dilute mineral acid with difficulty, while others such as the naphthyl-amines form sparingly soluble hydrochlorides and so may appear to be insoluble in the reagent. 

By employing simple primary amino adds, Xu and Wang achieved an enantioselective a-amination of branched aldehydes [54]. 3-(l-Naphthyl)alanine hydrochloride 7 was found to be the best catalyst, furnishing the desired amination products in moderate to excellent yields and very good enantioselectivities (Scheme 3.18). 

If it is heated alone at 160°, ammonia comes off rapidly, the aniline and phenylisocyanate may be detected by their odor but they combine in large part to form 5ym.-diphenyliu ea which crystallizes out from the hot liquid, and cyanic acid may be detected by means of silver nitrate in the water with which the apparatus is washed out after the experiment. When an aqueous solution of phenylurea is distilled, aniline may be detected in the distillate and 5ym.-diphenylurea crystallizes from the boiling liquid. By heating urea with the amine or with its hydrochloride at 160°, or by refluxing urea in aqueous solution with the amine or its hydrochloride, we have prepared sym.-6i-o- and />-tolyl, di-a- andjS-naphthyl, dimethyl, di-w-butyl, di-w- and i5 -amyl and dibenzylureas in satisfactory yield. 

Total chlorine is the sum of free and combined chlorine (defined as the residual chlorine existing in water in chemical combination with ammonia or organic amines). Total chlorine reacts with V,V-(l-naphthyl)-l,2-ethylendiamine hydrochloride and potassium iodide the compound formed is titrated as stated above. 

Deprotection of Fmoc-amino acid Wang resins under standard conditions yielded the polymer-bound amino acids 1. Condensation with 3,4-dichlorobenzaldehyde gave aldimines 2. Subsequent alkylation with electrophiles such as benzyl-, naphthyl- or allylbromide in the presence of 2-[(l,l-dimethylethyl)imino]- W,N-diethyl - 2,2,3,4,5,6- hexahydro-1,3-dimethyl-1,2,3-diazaphosphorin-2(lH)-amine (BEMP) gave the disubstituted aldimines 3. Transketalisation with hydroxylamine hydrochloride yielded the free amine 4 which was acylated and cleaved to give the final product 5 in good yields and purities. 

Branched and hindered aldehydes have been enantioselectively Q -aminated in high yield in THF solution at 0°C with azodicarboxylates, using a simple amino acid catalyst such as 3-(l-naphthyl)alanine, as its hydrochloride." An ion-pair catalyst formed by mixing a cinchona-derived diamine and camphor-sulfonic acid gives high yield and ee in direct amination of a-branched aldehydes, using azodicarboxylates." ... 

The standard method for the determination of nitrite in seawater is based on the reaction of nitrite with an aromatic amine leading to the formation of a diazonium compound which couples with a second aromatic amine. The product is an azo dye which is quantified by spectrophotometry. Early methods were modifications of the Griess-Ilosvay procedure where the nitrite diazotized with sulphamic acid. The diazonium salt then coupled with 1-naphthylamine. The method described below is generally accepted for seawater analysis and is based on the method proposed by Shinn (1941) and adapted for seawater by Bendschnei-der and Robinson (1952). This method is very sensitive and is unaffected by the presence of other constituents normally occurring in seawater. Sulphanilamide hydrochloride is used as the amino compound, which after diazotization is coupled with N-(l-naphthyl)-ethylene-diamine dihydrochloride. 

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