Naphthoquinones antiviral

Human cytomegalovirus (HCMV) disease is the most common life-threatening opportunistic viral infection in the inmunocompromised. HCMV protease, a serine protease, plays a critical role in capsid assembly and viral maturation and is an attractive target for antiviral chemotherapy. Slater et al investigated the interaction of various 1,4-naphthoquinones derivatives with HCMV protease. They identified potent irreversible naphthoquinones inhibitors of HCMV protease which covalently modify... 

Some Psychotria species, such as P. microlabastra [76], P. capensis [78], P. rostrata [79], and several species from the Atlantic Forest [80], have known antibiotic properties. Antiviral (P. serpens) [81], antiviral/antifungal, anti-inflammatoiy (P. hawaiiensis [82] and P. insularum [83]), and antiparasitical activities (P. camponutans [84] and P. klugii [70]) have also been reported. Other bioactivities include cytotoxic properties (P. prunifolia) [85] and regulation of human growth hormone release (P. oleiodes) [86]. The active molecules produced by Psychotria species include pigments [87], peptides [88], naphthoquinones [89], benzoquinones [90], and alkaloids [91]. 

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