Naphthalene scaffold

Rodriguez AL, Tamrazi A, Katzenellenbogen JA. Substituted naphthalene scaffolds as estrogen receptor coactivator mimics. Abstracts of Papers, 224th ACS National Meeting, Boston, Aug 18-22, 2002 MEDI-360. 

The naphthalene scaffold plays a crucial role in material, chemical, and biological sciences as it is used as an organic semiconductor, incorporated... 

Along similar lines, Feldman et al. used a naphthalene scaffold to construct hydrogen-bonded assemblies in the sohd state. Their results, which border on the field of crystal engineering, indicate that the dimerization occurs in a quasi-unimolecular fashion to afford the a-truxillate dimer in near-quantitative yield. The reported lack of photoreactivity in tetrahydrofuran (THF) solutions may be due to the weakness of the hydrogen-bonding interactions in those solvents suitable for solubilizing such compounds. 

I he diverse range of phannacological actions of this structural class documents the belief that the naphthalene nucleus consists of a scaffold upon which vanous functional groups can be arranged tnd that the action elicited is a consequence of receptor response to the kind and spatial arrange ment of these functions... 

Within their scaffolds, POPAM dendrimers also possess amine groups which can undergo protonation or coordination with metal ions. The spectroscopic and photochemical properties of the first to the fourth POPAM generation with peripheral fluorescing naphthylsulfonamide groups were compared with those of reference compounds A (N-methylnaphthalenesulfonamide) and B (N-(3-di-methylaminopropyl)-2-naphthalene-l-sulfonamide) [22] (Fig. 5.19). 

The core scaffold of three of the previously identified inhibitors, VI, SI, and S5 (31), is 4,5-dihydroxynaphthalene-2,7-disulfonate—structure A in Durrant et al. (47). Similarity searches were performed using three structures similar to this core scaffold naphthalene-2-sulfonic acid, 2-naphthoic acid, and 2-nitronaphthalene—structures B, C, and D in Fig. 1 of Durrant et al. (47), respectively. 

Diimide functionalities provide an attractive hydrogen-bonding scaffold for the association of donor acceptor pairs. In all the examples surveyed here, the electron acceptors are derivatized naphthalene- or benzene-tetracarboxamides these acceptors have proved particularly useful for analysis of electron transfer reactions owing to the characteristic absorptions of their anion radicals. Osuka, Okada,... 

In 2000, Katsuki and co-workers applied the chiral chloro nitrosyl Ru -(salen) complex developed in their own group to asymmetric aerobic oxidative biaryl coupling reactions (Scheme 3.14). The reaction was found to proceed smoothly in air under irradiation with a halogen lamp as the light source at room temperature. Examination of a series of Ru (salen) complexes revealed that the combination of (R,R)-diamine unit and (R)-BINOL scaffold in the catalyst is important for achieving higher enantioselectivity. The absolute configuration of the major product is determined by the chirality of the BINOL scaffold whereas the structural variation in the diamine part shows little influence on asymmetric induction. Under the optimal conditions, several 2-naphthols with a substituent at the C6 position of the naphthalene... 

Abstract— The aim of this study was to produce the absorbable BCP scaffolds from tricalcium phosphate (TCP) and hydroxyapatite (HA). The Naphthalene particles were used as pore forming agent. The conventional pressing and sintering were utilized to prepare disc shape samples. The sintering were carried out at the temperatures 1000,1100 and 1200 °C. The phase composition and chemical structure analyses were performed using XRD and FTIR experiments. The morphological aspects of scaffolds such as pore size and distribution and their interconnectivities were studied by SEM. 

Finally, the replacement of the coumarine scaffold by naphthalene derivatives was envisaged, and conversions of 15% to 45% were obtained for the methylation of some naphthalenediols, opening new perspectives for this green and selective Friedel-Craft alkylation. 

Fig. 44 Arene edge scaffolds (a) 1,8-disubstituted anthracenes (b) 1,8-disubstituted naphthalenes (c) 4,5-disubstituted xanthenes and (d) 1,3-disubstituted [4]caltxarenes [151-157, 165,166]...

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