Naphthalene diol, complexes

Complex formation towards 1,8-ANS and 2,7-naphthalene diol 36) has been studi l also for the macrocycles 45 and 46, which are homologous to 47 By affixing a pyridoxamine side chain to 46, the host 58 was obtained. The catalytic activity in the transamination of phenylpyruvate (59) to phenylalanine 60) and of a-ketovalerianic acid 61) to norvaline 62) was studied using this host. 

In this way using the host compound 63 below the CMC value = 2.5 x 10 the complexation of TNS (6) was determined by fluorescence spectroscopy The complex constant is of the same order of magnitude as the one of P-cyclodextrin With 2,7-naphthalene diol (56) as the guest no significant H-NMR highfield shifts could be obtained. The complex constant of 36 nevertheless was determined using the competitive inhibition of TNS. 

Tetrahydrofuran itself can be opened using either the stoichiometric or the catalytic version of arene-promoted lithiation, but both cases need the activation by boron trifluoride. The catalytic reaction was performed by treating the solvent THF 324 with the complex boron trifluoride-etherate and a catalytic amount (4%) of naphthalene. The intermediate 325 was formed. Further reaction with carbonyl compounds and flnal hydrolysis yielded the expected 1,5-diols 326 (Scheme 95), which could be easily cyclized to the corresponding substituted tetrahydropyrans under acidic conditions (concentrated FlCl). 

With DIOP-Pd(0) or -Ni(0) complexes as catalysts, moderate optical yields of up to 35% have been observed (126). Norbomene is convertible to the exo nitrile with up to 40% ee when a BINAP-Pd(0) complex is used (Scheme 57) (127). Ni(0) complexes of sugar-derived 1,2-diol phosphinites catalyze highly selective asymmetric addition of hydrogen cyanide to vinylarenes (128). This method gives the 2-naphthalene-2-propionitrile precursors of nonsteroid anti-inflammatory agents in up to 85% ee and in high yield. 

Beilstein Handbook Reference) AI3-18148 BRN 0742375 2,3-Dihydroxynaphthalene 2,3-Dihydroxynapthalene EINECS 202-166-7 2,3-Naphthalenediol Naphthalene-2,3-diol NSC 8707. Used as a complexing reagent. Crystals mp = 162-164°. 

RT and HIV PR is capable of reducing the viral load in blood patients. These enzymes, which exist respectively as a heterodimer and a homodimer for HIV RT and HTV PR, are well-characterized more than 170 structures of HIV PR and its complexes with various inhibitors have been solved by protein crystallography techniques. Thus, a dipalmitoylated derivative of 2,7-naphthalene disulfonic acid demonstrated micromolar activity for both fflV-1 and HIV-2 RT (Fig. 16.14). Symmetrical nature of HTV PR was used in the search for novel anti-HTV drugs that would embody the predicted characteristic of the active site. The design of inhibitors of HIV PR has led to symmetrical compounds, which can be divided into two groups (1) pseudosymmetrical compounds, like derivatives A 74704 ° and L 700,417 which contain asymmetric atoms in close proximity to the inhibitor two-fold axis (2) fully Ca-symmetrical inhibitors like the cyclic urea and the diol derivatives (Fig. 16.14). 

A] and the pairs are linked to other pairs by hydrogen bonds. Similarly, the 1 2 complex of 10-propylisoalloxazine (9) and naphthalene-2,3-diol consists of flavin-naphthalenediol pairs separated by 3.35 A, It has been... 

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