Nanospheres intracellular uptake

Intracellular infections were found to be a field of interest for drug delivery by means of nanospheres. Indeed, infected cells may constitute a reservoir for micro organisms, which are protected from antibiotics inside lysosomes. The resistance of intracellular infections to chemotherapy is often related to the low uptake of commonly used antibiotics or to their reduced activity at the acidic pH of lysosomes. To overcome these effects, the use of ampicillin, a p lactam antibiotic, bound to nanospheres was proposed as endocytozable formulation. The effectiveness of polyisohexylcyanoacrylate (PIHCA) nanospheres was tested in the treatment of two experimental intracellular infections. 

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