Nanoparticles passive targeting

Ceramic nanoparticles Passive targeting of cancer cells 33... 

One of the emerging strategies to overcome the drawbacks of dendrimers and dendritic nanomaterials is their hybridization with other types of nanoparticles, which is most commonly used in targeted cancer drug delivery. The tumor characteristic of enhanced permeability and retention (EPR) effect allows polymeric nanoparticles, micelles, and liposomes of relatively large size (typically 50-200 nm in diameter) to be selectively accumulated in tumor sites.[32] This size-based accumulation in tumor sites, called passive targeting, cannot be easily exploited by dendrimers due to their small size (<10 nm). In contrast, active... 

Passive targeting occurs due to extravasation of the nanoparticles at the diseased site where the microvasculature is leaky. Passive delivery refers to nanoparticle s transport through leaky tumor capillary fenestrations into the tumor interstitium and cells by passive diffusion or convection (Haley and Frenkel 2008). What is important to understand, passive targeting proceeds based on natural developed... 

Polymeric nanoparticles of different physical characteristics such as size, size distribution, morphology and zeta potential (charge) can be synthesized by controlling the parameters specific to the synthesis method employed. There are several techniques potentially useful for the preparation of polymeric nanoparticles. The selected method determines the characteristics of spheres, including the size, because it is one of the most important properties strongly related to mode of administration as well as passive targeting. Another property influenced by the preparation process is the ability to interact with active principles contained in the drugs formulation. 

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