Nanoparticles active targeting

Cancer Therapy Nanoparticles were first prepared with the concept of targeting colloidal carriers of nanosize to tumor tissues via the leaky vasculature in tumor regions. Since then nanoparticulate drug carriers have been associated with cancer therapy through passive and active targeting to cancer cells. Thus, amphiphilic CD nanoparticles were mainly focused on cancer therapy and its different aspects. 

Yan, Z. Li, Y. In vitro and in vivo evaluation of actively targetable nanoparticles for paclitaxel delivery PEG coated... 

Passive accumulation and physiological effects have been exploited for disease treatment in preclinical models for inflammation and cancer ° without surface modification or active targeting by ligand attachment. This may reflect the neovasculature associated with these conditions and the enhanced permeability and retention effect in tumors in which nanoscale particles migrate and accumulate across leaky vasculature in disease tissue. Relying on physiological conditions, however, limits the capability to control the location and dose and results in widespread biodistrihution commonly associated with unmodified nanoparticles that... 

Fig. 1 Structures of dendritic nanomaterials. (a) Dendrimers have a well-defined hierarchical structure consisting of a core, branch, and periphery, (b) Each generation is added to the structure by repeating the reaction sequence of stepwise synthesis, which generates two new branching points, (c) Dendrimers can be encapsulated into relatively large nanoparticles such as liposomes and polymeric nanoparticles (50-200 nm in diameter), which can aim both passive and active targeting strategies.

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