Nanoparticle photon correlation spectroscopy

Huve, P., Verrecchia, T., Bazile, D., Vauthier, C., and Couvreur, C., Simultaneous use of size exclusion chromatography and photon correlation spectroscopy for the characterization of poly(lactic acid) nanoparticles, /. Chromatogr. A, 675, 129, 1994. 

Kreuter and Speiser [77] developed a dispersion polymerization producing adjuvant nanospheres of polymethylmethacrylate) (PMMA). The monomer is dissolved in phosphate buffered saline and initiated by gamma radiation in the presence and absence of influenza virions. These systems showed enhanced adjuvant effect over aluminum hydroxide and prolonged antibody response. PMMA particles could be distinguished by TEM studies and the particle size was reported elsewhere to be 130 nm by photon correlation spectroscopy [75], The particle size could be reduced, producing monodisperse particles by inclusion of protective colloids, such as proteins or casein [40], Poly(methylmethacrylate) nanoparticles are also prepared... 

Kaszuba M (1999) The measurement of nanoparticles using photon correlation spectroscopy and avalanche photodiodes. J Nanoparticle Res 1 405-409... 

Photon Correlation Spectroscopy Diameters of Solid Lipid Nanoparticles... 

Photon Correlation Spectroscopy Diameters of Solid Lipid Nanoparticles Produced with Different Matrix Lipids (10% Lipid, 1 % Poloxamer 188) to Assess the Influence of the Matrix Lipid on the Cytotoxicity toward Peritoneal Mouse Macrophages... 

Photon Correlation Spectroscopy Diameters of Dynasan 114 Solid Lipid Nanoparticles with Different Surfactants (10% Lipid, 1% Surfactant) to Assess the Influence of Different Surfactants on the Enzymatic Degradation (Lipase/Colipase) of Solid Lipid Nanoparticles... 

FIGURE 1.164 Interaction of to oxide nanoparticles with a globular protein and a certain number of water molecules (CharMM calculations). (Adapted from Adv. Colloid Interface ScL, 105, Gun ko, V.M., Klyueva, A.V., Levchuk, Yu.N., and Leboda, R., Photon correlation spectroscopy investigations of proteins, 201-328, 2003b. Copyright 2003, with permission from Elsevier.)... 

Figure 9.4. Cryo-TEM images and proposed interpretation of the colloidal structures of lipid nanoparticles with different lipid matrixes and stabilized with poloxamer 188. NEmu-10% MCT emulsion, SLN glyceryl behenate. NLC-1.0 and NLC-3.0 glyceryl behenate/MCT mixture 9 1 and 7 3 (w/w). Reprinted from J. Control. Rel., Vol. 95, K. Jores et ah, Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid Upid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy, 217-227. Copyright (2004), with permission from Elsevier.

Figure 10.9. DSC heating and cooling curves (5°C/min) of cholesteryl myristate in the bulk and in colloidal dispersion (5% CM, 2% PVA PCS z-average 172 nm, PDI 0.09). With kind permission from Springer Science + Business Media Fharm. Res. Supercooled smectic nanoparticles A potential novel carrier system for poorly water soluble drugs, 21, (2004), 1834-1843, J Kuntsche et al. Abbreviations DSC differential scanning calorimetry, PVA polyvinyl alcohol, PCS Photon correlation spectroscopy, PDI Polydispersity index.

The flowability of SD and SFD powders containing nanoparticles was assessed by measuring the bulk and tap density of the powder. Dissolving the powder in deionized water to form a colloidal dispersion and comparing the nanoparticle size before and after SFD and SD processing measured the reconstitution-rate of spray-dried and spray-freeze-dried nanoparticle formulations as described in Ali and Lamprecht [16]. The nanoparticle size was determined by photon correlation spectroscopy (Brookhaven Instruments Corporation, Holtsville, NY, USA) [16]. 

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