Nanomaterials antibiotics

Keywords Biotoxins, Coccidiostats, Food contaminants, LC-MS/MS, Nanomaterials antibiotics, Perfluorinated compounds. Pesticides, Polybrominated diphenylethers... 

Strassert CA et al (2009) Photoactive hybrid nanomaterial for targeting, labeling, and killing antibiotic-resistant bacteria. Angew Chem Int Ed 48 7928-7931... 

Bacterial infection is a common problem associated with orthopedic implantation procedures, causing serious complications in host tissues, failure of orthopedic implants, and even death of patients. Although antibiotics are widely used, problems of toxicity, antibiotic resistance, adverse responses of patients, short effective time, and availability always demand better approaches to prevent infection. Therefore, a new area of preventing infection has emerged by utihzing the extraordinary surface properties of nanomaterials (such as ultrasmall structures, increased surface area and roughness, increased grain boundaries, etc.) for antibiotic purposes. 

In addition to carbon based nanomaterials, precious metal particles can also be used as matrices in SALDI-MS analysis. A recent report highlights the use of liquid-liquid microextraction sample preparation for the analysis of macrohde antibiotics in biological fluids such as urine, using coUoidial silver as the SALDI matrix. In comparison to CHCA, the coUoidal silver offered a significantly superior performance with respect to homogeneity, robustness, and sensitivity [35]. 

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