NANOMATERIAL-BASED LABEL-FREE APTASENSORS

More than four decades ago, reports regarding electrochemical signals from DNA appeared in the literature (Palecek, 1958). Voltammetry of native and denatured 

Aptamers in Bioanalysis, Edited by Marco Mascini Copyright 2009 John Wiley Sons, Inc. 

In an effort to increase the sensitivity of label-free voltammetry, we can utilize carbon nanotubes (CNTs) as the transducing surface of our aptasensors. It has been well established that the electrochemical responses of DNA are greatly 

The label-free voltammetry of DNA and proteins has been known for a long time bnt has recently started to blossom as an exciting field which new researchers are tempted to pursne with high motivation. With the endless possible combinations of amino acids in peptides and proteins, as well as the nucleobases in DNA and RNA, an immense variety of voltammetric signals can be obtained as a resnlt of aptamer-protein interactions. Since the method does not require any 

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We are presently in the early days of the emerging technology of using aptamers and nanomaterials to modify biosensors. So far, thrombin-binding aptamer has been the topic of numerous reports, but although many improvements are required in reproducibility and sensitivity, there is no doubt that a growing number of aptamers and, it is to be hoped, nanomaterial-based label-free aptasensors will soon be used for the diagnosis and therapeutic follow-up of diseases. 

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