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NANC Transmission/Mediators

Inhibitory NANC responses are mediated by both VIP and NO.. NO. partially mediates the airway smooth muscle relaxant effects of VIP in the isolated perfused guinea-pig lung, as NOS inhibitors prevent relaxation induced by VIP but not that induced by isoproterenol (Lilly et al., 1993b). A significant and appropriately timed increase in the NO. content of lung perfusion fluid can be measured in response to VIP (Fig. 7.4). These data support the conclusion that interactions of VIP with NO. products mediate a substantial component of iNANC transmission. In human airways, NOS stimulated as a result of iNANC neurotransmission accounts for a substantial proportion of this relaxant response. Bel-visi and co-workers have shown that the a-chymotrypsin-resistant component of the human iNANC response can be abolished by treatment with NOS inhibitors (Belvisi et al., 1992). [Pg.137]

See other pages where NANC Transmission/Mediators is mentioned: [Pg.820]    [Pg.820]    [Pg.868]    [Pg.868]    [Pg.1497]    [Pg.1498]    [Pg.820]    [Pg.820]    [Pg.868]    [Pg.868]    [Pg.820]    [Pg.820]    [Pg.868]    [Pg.868]    [Pg.1497]    [Pg.1498]    [Pg.820]    [Pg.820]    [Pg.868]    [Pg.868]    [Pg.580]    [Pg.129]    [Pg.578]   


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NanCs

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