Naltrexone Rating Scale

A double-blind crossover study of naltrexone (1 mg/kg/day, 2 weeks) in 13 children with autistic disorder found significant improvement over placebo with respect to both parent and teacher ratings on the CGI scale, the impulsivity-hyperactivity factor of the Connor Rating Scale, and restlessness on the Naltrexone Side Effect Rating Scale. Overall, 8 of the 13 subjects demonstrated modest improvement during the naltrexone treatment phase. No significant adverse effects of naltrexone were observed, although the bitter taste of naltrexone was a problem for some children. 

In the Expert Consensus survey (Rush and Frances, 2000), the respondents identified newer atypical anti-psychotics and anticonvulsants or mood stabilizers as first-line treatments for self-injury. Antidepressants, naltrexone, and conventional antipsychotics were given ratings at least midway or higher on the scale provided. 

FIG. 4. The reflex acquisition of rats exposed to saline or MAM (14 mg/kg) prenatally with saline or naltrexone (50 mg/kg) given postnatally is shown. All groups acquired basic motoric skills at the same rate. Early-life motor performance, such as measured with the Bayley scales, is a poor predictor of late-life IQ in humans. 

Combined morphine/naltrexone capsules have shown comparable analgesia, adverse effects and bioequivalence to a similar morphine sulfate extended-release capsule product (Kadian ) with regard to rate and extent of plasma morphine absorption [8]. In the clinical efficacy trial in patients with pain due to osteoarthritis, change in the weekly BPI average pain score was statistically significantly superior for those treated with Embeda as compared to placebo. A review of the Subjective Opiate Withdrawal Scales (SOWS)... 

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